Victor Tybulewicz obtained his PhD at the MRC Laboratory of Molecular Biology,
Cambridge, working with John Walker on ATP synthases. He then carried out
postdoctoral research at the Whitehead Institute, MIT with Richard Mulligan,
developing methods for gene targeting in mice.
In 1991 he moved to the MRC National Institute for Medical Research, London where
he runs an independent research group working in two main areas. Firstly he studies
signal transduction in lymphocytes, exploring the roles of signaling molecules in B
and T cell development, activation and survival. Secondly, in collaboration with
Elizabeth Fisher, he is using mouse genetics to understand the pathology of Down
Syndrome. Together they generated the first ever transchromosmic mouse strain,
Tc1, which carries a freely-segregating copy of human chromosome 21, and shows
phenotypes resembling the human condition. He has published over 160 papers in
peer-reviewed journals.
In addition to running his own research group, he was Head of the Division of
Immune Cell Biology and Head of the Immunity Supergroup at the MRC National
Institute for Medical Research. On 1st April 2015 the MRC NIMR became part of the
Francis Crick Institute, and Victor Tybulewicz is now a Senior Group Leader at this
Institute.
He is a Member of the European Molecular Biology Organization and a Fellow of the
Academy of Medical Sciences.